INDIGO Biosciences Releases a Family of Cell-Based Reporter Assays for the Adrenergic Receptors

State College, PA (February 21th, 2024) – INDIGO Biosciences announced today the release of new cell-based reporter assays for the family of Human Adrenergic Receptors, including ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2.

A New Family of Assays Including ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 for Preclinical Research of Heart Failure, Hypertension, Obesity, and Respiratory Conditions

“INDIGO is very pleased to release this new family of robust, highly sensitive assays,” said INDIGO’s Chief Technology Officer, Bruce Sherf PhD. “Since the Adrenoceptors are expressed in a variety of smooth tissues, they are integral in many physiological processes pertaining to the human sympathetic nervous response.”

Adrenergic receptors are a class of G protein-coupled receptors (GPCRs) that play a pivotal role in mediating the physiological effects of the sympathetic nervous system which is responsible for the “fight-or-flight” response. These receptors are integral components of the human body's response to stress, regulating a multitude of functions ranging from heart rate to bronchodilation. The diverse roles of adrenergic receptors in health and disease make them attractive targets for researchers in drug discovery related to heart failure, hypertension, obesity, and respiratory conditions. Read More